Glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. Sensitizes neurons in hippocampus to depolarization by L-AP6 (the so called 'quis' effect).

1-BCP is can modulate AMPA receptor gated currents and enhence memory.

β-ODAP is an analog of glutamic acid present in Lathyrus sativus (grass pea) that activates AMPA receptors.

CX 614 is a positive allosteric modulator of AMPA receptors.

Naspm 3HCl is a potent and selective Ca2+ permeable AMPA receptor (Ca-perm AMPAR) blocker.

Noopept is a potent nootropic that improves cognitive ability.

CX-546 is a AMPAR potentiator which can destabilize the desensitized receptor conformation.

CP 465022 HCl is a selective, non-competitive AMPA receptor antagonist (IC50 = 25 nM in rat cortical neurons) that displays potent anticonvulsant activity.

LY451395 is a potent and highly selective potentiator of the AMPA receptors.

CNQX is a potent and selective non-NMDA iGluR antagonist.

Coluracetam a nootropic which can increase the potency of AMPA receptors.

Farampator (CX-691;Org24448) is an AMPA receptor positive modulator.

DNQX is a selective non-NMDA iGluR antagonist.

IDRA-21 is a positive AMPA receptor modulator. IDRA-21 inhibits synaptic and extrasynaptic NMDA receptor mediated events in cultured cerebellar granule cells. IDRA 21 enhances ischemic hippocampal neuron injury.

NBQX is a potent, selective and competitive AMPAR antagonist, which shows activity of neuroprotective and anticonvulsant.

JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models[1].

Ampalex is a positive allosteric modulator of AMPAR and is researched as a treatment for Alzheimer's disease.

Kynurenic Acid is a broad spectrum glutamatergic antagonist which can antagonize NMDA, kainate and AMPA receptors.

Aniracetam is an allosteric modulator of AMPAR which can reduce glutamate receptor desensitization and potentiate metabotropic glutamate receptor activity.

Piracetam is a cyclic derivative of GABA which works as a positive allosteric modulator of the AMPA receptor.