Calceolarioside B is a natural product isolated and purified from the herbs of Ajuga becumbens Thunb. with an anti-proliferation property.

Poliumoside is a natural compound which exhibit significant inhibition of advanced glycation end product formation with IC50 values of 4.6-25.7 μM

3-bromo-5-phenyl Salicylic Acid is a cell-permeable salicylic acid compound that acts as a highly potent, active-site directed and substrate competitive AKR1C1 inhibitor (Ki = 4 nM) with moderate to excellent selectivity over AKR1C2, AKR1C3 and AKR1C4 (Ki = 0.087, 4.2 and 18.2 µM, respectively).

Alrestatin is an inhibitor of aldose reductase, an enzyme involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy.

Ziyuglycoside II, a natural product isolated and purified from the roots of Sanguisorba officinalis, with anti-inflammation, antioxidation, antibiosis, homeostasis, and antitumor properties against gastric cancer and breast cancer cells, by cell cycle arrest and cell apoptosis.

Aldose reductase-IN-1 is an inhibitor of aldose reductase with IC50 of 28.9 pM.

Soyasaponin Bb, a triterpenoid saponin that has been found in soy, selectively inhibits human recombinant renin (IC50 = 30 μg/ml). It can also inhibit the mouse brain sialyltransferase ST3GAL1 (Ki = 2.1 μM).

Nodakenetin is a natural product isolated and purified from the herbs of Peucedanum decursivum Maxim. with clinical efficacy.

Imirestat is an inhibitor of aldose reductase which is used for the treatment of diabetes.

Statil is a selective and noncompetitive aldose reductase 2 inhibitor with Ki value of 7.7nM.

Zopolrestat is a aldose reductase inhibitor.

AT-007 is a central nervous system (CNS) penetrant Aldose Reductase inhibitor (ARI) in Phase 1/2 development for treatment of Galactosemia.

Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM, and used for the treatment of diabetic neuropathy.

Isoliquiritigenin is a licorice chalconoid, a type of natural phenols, and a sirtuin-activating compound.

Byakangelicin, a main furanocoumarin constituent isolated and characterized as an aldose reductase inhibitor from the roots of Angelica dahurica, is an aldose reductase inhibitor and induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes.