CCT128930 is a potent ATP-competitive, selective Akt2 inhibitor with an IC50 of 6 nM and > 28-fold selectivity for Akt2 than the closely related PKA kinase.

BAY1125976 is a selective allosteric AKT1/2 inhibitor and inhibits AKT1 and AKT 2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively.

ARQ 092 is a pan-Akt inhibitor with IC50 values of 5nM, 4.5nM and 16nM for Akt1, Akt2 and Akt3, respectively, through blocking membrane translocation of inactive AKT and even dephosphorylating the membrane-associated active form.

A-443654 is a potent small-molecule inhibitor of all three Akt serine/threonine kinases, induces Akt Ser-473 phosphorylation in all human cancer cell lines tested, including PTEN- and TSC2-deficient lines.

API-1 is a selective Akt/PKB inhibitor and shows antitumor activity.

TIC10 is a brain-permeable and pharmacokinetics-improved Akt inhibitor, also inactivates ERK.

FPA 124 is an inhibitor of Akt/PKB with IC50 of 100 nM that interacts with the PH and kinase domains.

A-674563 is a potent selective Akt1 inhibitor with an IC50 of 14 nM. It also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.

Oridonin is an antitumor agent, a diterpenoid purified from Rabdosia rubescens. Oridonin interacts with the cysteine 279 of NLRP3 NACHT domain through a covalent bond, abolishes NLRP3-NEK7 interaction, and inhibits consequent activation of NLRP3 inflammasome.

CAY10404 is a potent and highly selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 1 nM. CAY10404 exhibits no inhibition of COX-1 (IC50>500 µM) . CAY10404 is a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSCLC cells. CAY10404, a diarylisoxazole, has good analgesic, anti-inflammatory, and anti-cancer activities .

Phellodendrine HCl, a natural product isolated and purified from the cortex Phellodendri chinensis with anti-nephritic activity, may be due to its ability to inhibit the proliferation or the migration of macrophages and cytotoxic T lymphocytes in the glomeruli. Phellodendrine is against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway.

Psoralidin, a natural furanocoumarin, is isolated from Psoralea corylifolia L. with anticancer and chemopreventive properties, inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation.

ARQ-092 is an orally bioavailable, selective, and potent allosteric Akt inhibitor with IC50 of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively.