Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 μM for Z- and E-Guggulsterone, respectively.

Ethyl gallate is a natural product isolated and purifeid from the herbs of Coriaria nepalensis, and it can inhibit the abilities of invasion of breast cancer in vitro by inhibiting the mRNA levels of MMP-9/MMP-2, phosphorylation of Akt and protein expression of NF-κB.

YS 49 inhibits Ang II-stimulated proliferation of VSMCs via induction of HO-1.

Musk ketone, insoluble in water, can increase activity of glutathione S-transferase and thus may prove to be useful cancer chemoprotectant.

Rutundic acid, a natural product isolated and purified from the leaves of Ilex pubescens Hook. et Arn. with antitumor activity, exhibits potent tumor cell growth inhibiting property against Hela, A375, HepG2 , NCI-H446, and SPC-A1.

AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, exhibiting little activity outside the AGC kinase family.

Chonglou saponin VII, a natural product isolated and purified from the roots of Paris polyphylla, shows inhibitory effects on cell proliferation.

GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, 620-fold selectivity over PKA.

Crebanine, a natural product isolated and purified from the herbs of Stephania yunnanensis, can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, decrease the incidence of VF and CA by CaCl_2 in rats and by chloroform in mice, but has no proteetive effects on ouahain-indueed arrhythmias in guinea pigs.

Deguelin is a naturally occuring Akt inhibitor purified from the herbs of Derris robusta, which downregulates Akt phosphorylation and shows anticancer effect.

SC66 is an allosteric and dual-inhibitory-function inhibitor of Akt which can lead to a reduction in total and phospho-AKT levels.