Galangin functions as an antagonist of the aryl hydrocarbon receptor and also inhibits CYP1A1 (IC50 = 1 μM). It belongs to flavonoids and can be extracted from the rhizome of Zingiber officinale Roscoe with anti-inflammatory properties.

Indole-3-Carbinol is a naturally occuring plant hormone found in cruciferous vegetables, which can both inhibit carcinogenesis in several animal species and enhance tumor incidence if administered at a post-initiation stage.

Benvitimod is a non-steroidal anti-inflammatory drug (NSAID) potentially for the treatment of atopic dermatitis.

Aryl Hydrocarbon Receptor (AhR) Agonists, Signal Transduction Modulators

Formononetin can act as an agonist of aryl hydrocarbon receptor (EC50 = 130 nM) and has prevention of breast cancer, prostate cancer and colon cancer. Formononetin could be extracted from the bark of Ononis natrix L..

PDM 11 is a derivative of the antioxidant trans-resveratrol.

Aryl Hydrocarbon Receptor (AhR) Agonists, Signal Transduction Modulators

UM729 is an enhancer of aryl hydrocarbon receptor (AhR) antagonists.

DiMNF is a selective aryl hydrocarbon receptor (AHR) modulator (SAhRM).

GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with IC50 of 62 nM.

StemRegenin 1 is an AhR antagonist with IC50 of 127 nM. Also, it stimulates the proliferation and differentiation of CD34+ hematopoietic progenitor cells.