Mal-PEG3-acid is a PEG derivative containing a maleimide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196).

N-Boc-PEG3-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

N-Succinimidyl 4-(2-pyridyldithio)pentanoate is a bis-sulfone linker for antibody-drug-conjugation (ADC).

4-Pentynoic acid succinimidyl ester is a linker for antibody-drug-conjugation (ADC).

DBCO-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Linker for Antibody-Drug-Conjugation (ADC). The Val-Cit will specifically be cleaved by catepsin B. As this enzyme is only present in the lysosome the ADC payload will be release only in the cell.

(2-pyridyldithio)-PEG1-hydrazine is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Mal-PEG2-NHS is a PEGn linker for antibody-drug-conjugation (ADC).

N-Succinimydyl-(3-(2-pyridyldithio)propionate) hexanate is a bis-sulfone linker for antibody-drug-conjugation (ADC).

Propargyl-PEG3-acid is a non-cleavable (3 unit PEG) ADC linker and also a PEG-based PROTAC linker that can be used to synthesis 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA (HY-B1081, HY-B1081A) and Propargyl-PEG3-acid.

Mc-Val-Cit-PABC-PNP is a linker for ADC through cleaveage by catepsin B only present in lysosome at Val-Cit site, thus making ACD payload be released only in the cell.

Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Mal-PEG4-NHS ester is a PEGn linker for antibody-drug-conjugation (ADC).

Perfluorophenyl 3-(pyridin-2-yldisulfanyl)propanoate is a bis-sulfone linker for antibody-drug-conjugation (ADC).

Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196).

Mal-PEG3-PFP is a PEGn linker for antibody-drug-conjugation (ADC).

Mal-PEG-NHS is a PEGn linker for antibody-drug-conjugation (ADC).

NH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).