Coclaurine, a natural product isolated and purified from the root of Coptis chinensis Franch, blocks postsynaptic but not presynaptic dopamine receptors in the mouse striatum.

Piperidolate is a muscarinic receptor antagonist which inhibits the action of acetylcholine at postganglionic cholinergic sites.

TBPB is an allosteric M1 mAChR agonist (EC50=289 nM) that regulates amyloid processing and produces antipsychotic-like activity in rats.

(R)-Fesoterodine fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist.

Benzetimide HCl is a muscarinic acetylcholine receptor antagonist.

VU 0238429 is a selective positive allosteric modulator of M5 receptors with EC50 values of 1.16, >30 and >30 μM at M5, M1 and M3 receptors respectively.

PHA 568487 is agonist of the α7 nicotinic acetylcholine receptor with Ki value of 44.

VU0119498 is a M1 muscarinic receptor agonist with EC50 of 3.1 μM, and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent.

Tiotropium bromide is amAChR antagonist which acts through blocking the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

VU 0255035 is a highly selective and brain penetrant M1 antagonist with Ki value of 14.87 nM, targeting the M1 orthosteric site.

VU 0152100 is a potent and selective allosteric potentiator of M4 mAChR with an EC50 of 380 ± 93 nM.

Xanomeline Oxalate is a selective M1 muscarinic receptor agonist.

Xanomeline is a functionally selective M1/M4 agonist, used in the study of both Alzheimer's disease and schizophrenia.

Tacirne is an active cholinesterase inhibitor that blocks the degradation of cholinergic nerves in the cerebral cortex and hippocampus to increase cholinergic transmission. Tacrine induces hepatic damages in vitro. It can also induce oxidative stress and mitochondrial dysfunction. Tacrine treatment in HepG2 cells markedly inhibits the phosphorylation of GSK3β.